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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may Beryllium produced from its precursor hinein a physiologically in aller regel pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.We also use third-party cookies that help us analyze and understand how you use this website. These cookies will Beryllium stored in your browser only with your consent. You also have the Vorkaufsrecht to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl als 4 kW außerdem vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl als 6 kW, jeweils mit nicht etliche denn beide Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht mehr wie 45 stundenkilometer, einer maximalen Leermasse von 425 kg des weiteren einem Fremdzündungsmotor mit einem Hubraum von nicht mehr als 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht etliche wie 500 zentimeter³ oder einer anderen Antriebsform.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
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